The
nanocapsules and planar membranes are made from amphiphilic copolymers.
The copolymers are formed into hollow vesicles or planar membranes
through self-assembly methods. The vesicles or planar membranes
can be stabilized by crosslinking the copolymers to form nanocapsules
or stabilized planar membranes. The amphiphilic copolymers can be
ABA copolymers, where one of A and B is hydrophilic and the other
is hydrophobic. The nanocapsules can be used for a number of purposes.
In one embodiment, the nanocapsules are used to deliver a therapeutic,
prophylactic, or diagnostic agent to a patient in need thereof.
For example, if an ABA copolymer is used, a hydrophilic drug can
be encapsulated inside the vesicles or a hydrophobic drug can be
encapsulated in the middle layer of the vesicle membrane. Molecules,
such as membrane proteins, can be incorporated into the wall of
the nanocapsules to render them porous.
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